This Barnacle-Inspired Glue Seals Bleeding Organs in Seconds

Then the pigs arrived. Yuk loops with a Mayo Clinic team that is better equipped to operate multiple animals. The team wants to avoid relying on the blood’s natural ability to regulate, as many people who undergo surgery have self -regulatory issues. That is, before any experiments, the three test pigs received heparin, a thinner in the blood. The researchers identified three holes, 1 centimeter wide and 1 centimeter deep, in each of the animals ’veins, after which treated nine wounds with the correct adhesive or a TachoSil patch.

Tiffany Sarrafian, one of the team’s veterinary surgeons, said she has never seen anything work like this glue. “We just put the paste in, and we counted” for a few seconds, as Sarrafian said, remembering the procedure. “You open your hand and you say, ‘Hang-up, no blood!’ It’s really weird. ”

Sarrafian planned that if comparing the commercial patch didn’t work after three minutes, he would turn on the anticoagulant to keep the pigs alive, and then allow them to shake and heal naturally. But he added another step to stop the bleeding more quickly: putting a resisted measured pea on the experimental glue. “It was a miracle, in a way,” he said.

To be fair, coagulant patches like TachoSil are not designed to stop heavy blood streams from tissue without preventing damage. However, in medicine, that’s not necessarily necessary, according to Christoph Nabzdyk, a surgeon on the May team. “In the aging population, you have a lot of patients who get bleeding disorders or end up in the blood,” he said. “The problem of bleeding, and prevention of bleeding is important.”

They added Saraffian had a cheap adhesive that would stop a lot of bleeding and keep wet surfaces can be life -saving for patients, and they are especially useful in areas that do not have many surgical resources, such as deserted areas, battle zones, or less developed countries.

“Nothing in the material is really new, but this concept is cool and unusual,” said Shrike Zhang, a biomedical engineer who heads a lab at Harvard Medical School. While materials like silicon oil and adhesive components are common, it is combination makes for something exciting. “It’s very early, but the animal data is pretty strong,” he continues.

However, Wang, a Stanford cardiothoracic surgery resident, said there are still elements that need to be optimized before the adhesive can be applied to people. A globe of glue that seals the damaged tissue in an emergency, or stays around healthy tissue, can complicate any surgeries that follow. “The question is, will you be able to operate in that area?” he asked.

Yuk’s team devised a solution to restore this type of adhesive stamp, and introduction result in rats promised.

They also want to know how long this stamp will last; In fact, it should not dissolve until the tissue has healed on its own, but neither should it last forever. The new study showed that the paste dissolved within 12 weeks, consistent with microscope images in a separate experiment using rats. Depending on the damage and response to repair, that’s probably a lot.

Another challenge is other types of sealants that are known to kill tissue over time. Wang – and Yuk – remember that a long study is necessary. Currently, their longest observation of bleeding organs is about a month after application of the glue, using pigs from the Mayo Clinic trial.

And while it may still be many years before a sealant replaces reliable suturing, both surgeons and mechanical engineers will embrace the ability to glue patients quickly, so that bodies can run. such as engines with too much oil.

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